SYNTHETIC ANTIMALARIAL DRUG THERAPY IN LUPUS ERYTHEMATOSUS AND POLYMORPHOUS LIGHT ERUPTIONS
Identifieur interne : 003E82 ( Main/Exploration ); précédent : 003E81; suivant : 003E83SYNTHETIC ANTIMALARIAL DRUG THERAPY IN LUPUS ERYTHEMATOSUS AND POLYMORPHOUS LIGHT ERUPTIONS
Auteurs : John H. EpsteinSource :
- California Medicine [ 0008-1264 ] ; 1960-02.
English descriptors
- Teeft :
- Adenosine, Adenosine triphosphate, Antimalarial, Antimalarial agents, Antimalarial drugs, Aplastic anemia, Atabrine, Camoquin, Chloroquine, Chloroquine therapy, Chronic lupus erythematosus, Dermat, Discoid, Discoid lupus erythematosus, Dosage schedules, Eruption, Erythematosus, Exfoliative dermatitis, Inhibitory effect, Light eruptions, Lupus, Lupus erythemato, Lupus erythematosus, Malarial agents, Minerva dermat, More light, Plaquenil, Polymorphous light eruptions, Rheumatoid arthritis, Side effects, Skin discoloration, Synthetic antimalarials, Yellow discoloration.
Abstract
The therapeutic efficacy of the synthetic antimalarial agents in lupus erythematosus and the polymorphous light eruptions is well established. Severe toxic reactions are rare but mild disturbances are relatively common. Although gold therapy probably is as effective in discoid lupus erythematosus, the antimalarials are easier to administer and cause fewer serious side effects. The mechanism of action of these drugs is poorly understood although definite anti-inflammatory properties have been noted. Perhaps further investigations of known biological processes such as free radical formation and neutralization, redox potential alterations or enzymatic changes may shed more light on this problem.
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